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Manic Mouse Made With One Gene Missing Bipolar Disorder BPD or
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| manicdepressive illness is one of the most serious of all mental disorders affecting millions of individuals worldwide Affected individuals alternate between states of deep depression and mania Now a mouse model of the disease has been developed Researchers found that the glutamate receptor 6 GluR6 gene is associated with bipolar disorder Mice that were missing the GluR6 gene underwent a series of tests designed to approximate the symptoms of mania These mice showed many of the symptoms of mania including hyperactivity aggressiveness driven or increased goaldirected pursuits risktaking and supersensitivity to amphetamine The researchers also found that treating the mice with lithium the classic treatment for bipolar disorder reduced these symptoms |
03-14-08
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